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Gnathostoma is a genus of parasitic nematodes. The species Gnathostoma spinigerum and Gnathostoma hispidum can cause gnathostomiasis.
Neurognathostomiasis occurs in the USA. Gnathostoma binucleatum (which is native to the Americas) has not been previously reported to cause neurognathostomiasis, suggesting that G. spinigerum has been introduced to the Americas, but a survey of isolates has not confirmed this.